Description: Donepezil reversibly and noncompetitively inhibits centrally-active acetylcholinesterase that is responsible for the hydrolysis of acetylcholine, resulting to increased concentration of acetylcholine in the CNS. This happens more often in people with heart problems. Kawashima T, Yamada S "Delirium caused by donepezil: a case study." Call your doctor at once if you have: slow heartbeats; a light-headed feeling, like you might pass out; new or worsening stomach pain, heartburn, nausea, or vomiting; a seizure; Drug information provided by: IBM Micromedex. Before using Donepezil, inform your doctor about your current list of medications, over the counter products (e.g. These effects usually last 1-3 weeks and then lessen. How to store Donepezil 6. All rights reserved. Pharmacokinetics: Absorption: Well absorbed from the GI tract.Time to peak plasma concentration: 3-4 hr. This content does not have an Arabic version. The following side effects have been reported by people taking donepezil hydrochloride. Side effects can be less likely for people who start treatment by taking the lower prescribed dose for at least a month (see ‘Taking the drugs’). Donepezil may cause side effects such as dizziness or tiredness. 2. You may need urgent medical treatment. vitamins, herbal supplements, etc. Other side effects include: fatigue, muscle cramps, vomiting, weight loss, anorexia, and ecchymoses. It also increases the risk of side effects. Common side … pregnancy, upcoming surgery, etc. Keep this medication in the container it came in, tightly closed, and out of reach of children. O 0. Last updated on Oct 25, 2020. Serious side effects: You must tell your doctor immediately if you notice these serious side effects mentioned. Common side effects may include: nausea, vomiting, diarrhea; loss of appetite; muscle pain; sleep problems (insomnia); or feeling tired. If so, it’s important that you tell your doctor or pharmacist before you start donepezil. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. "Product Information. 2.1Dementia is a chronic progressive mental disorder that adversely affects higher cortical functions including memory, thinking, orientation, comprehension, … Consult your doctor before taking Aricept if pregnant or breastfeeding. Chest Pain 10. The side effects of memantine are less common and less severe than for the cholinesterase inhibitors. Sometimes a medicine isn’t suitable for a person with certain conditions or it can only be used with extra care. Manufacturer makes no recommendation. The more common side effects that can … WHAT DONEPEZIL HYDROCHLORIDE IS AND WHAT IT IS USED FOR Donepezil hydrochloride belongs to a group of medicines called acetylcholinesterase inhibitors. Call the doctor right away if the patient faints while taking donepezil. What should I know about storage and disposal of this medication? Donepezil may cause other side effects. ), allergies, pre-existing diseases, and current health conditions (e.g. Ann Pharmacother 34 (2000): 1347, 9. Check with your doctor as soon as possible if any of the following side effects occur while taking donepezil: Frequency of common adverse effects may be influenced by the rate of titration. Contents of the pack and other information 1. Morning dosing of donepezil is recommended to minimize insomnia. All rights reserved. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor. vitamins, herbal supplements, etc. Conclusion: Serious adverse reactions to donepezil can occur in elderly patients, who typically require multiple medications for a variety of comorbidities. How to take donepezil. Lam W "Pharmacological treatment of cognitive deficits in Alzheimer's disease." What DONEPEZIL is and what it is used for Donepezil belongs to a group of medicines called acetylcholinesterase inhibitors. Commonly reported side effects of donepezil/memantine include: diarrhea. Because there have been limited trials of donepezil in MS and the results have been mixed, the current evidence of the efficacy of donepezil on cognitive function in people with MS is unclear. Drinking alcohol stops donepezil from working as well as it should. There are rare serious effects such as fits. Donepezil is a centrally acting reversible acetylcholinesterase inhibitor and structurally unrelated to other anticholinesterase agents. Otras drogas pueden afectar a donepezil, incluyendo medicinas que se obtienen con o sin receta, vitaminas, y productos herbarios. Learn about side effects, drug interactions, dosages, warnings, and more. Donepezil is indicated for the treatment of dementia of the Alzheimer's type. Although not all of these side effects may occur, if they do occur they may need medical attention. Taking donepezil together with certain medicines that are used during surgery or dental or emergency treatments may increase the effects of those medicines and cause unwanted effects. It is unknown if Aricept is harmful to a fetus. Like all medicines, donepezil can cause side effects, although not everyone gets them. Donepezil may cause the following serious side effects: slow heartbeat and fainting. If you notice any other effects, check with your healthcare professional. Whereas donepezil is a once-a-day medication, rivastigmine is bid to tid and must be titrated up slowly. Fluid Retention In The Legs, Feet, Arms Or Hands 15. Neurology 61 (2003): 1452, 7. You may report side effects to FDA at 1-800-FDA-1088. Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others. Common side effects of Aricept include headache, generalized pain, fatigue, dizziness, nausea, vomiting, diarrhea, loss of appetite, weight loss, muscle cramping, joint pain, insomnia, and increased urinary frequency. Common side effects include nausea, trouble sleeping, aggression, diarrhea, feeling tired, and muscle cramps. ).Some health conditions may make you more susceptible to the side-effects of the drug. Below is a summary of known side effects for Donepezil. These side effects may go away during treatment as your body adjusts to the medicine. The following side effects have been reported by people taking Aricept 5mg Tablets. Blurred Vision 7. Trouble sleeping can be a side effect of donepezil but should subside with continued use. Donepezil is not mutagenic in bacterial and mammalian cell mutation assays. Rozzini L, Ghianda D, Trabucchi M, Padovani A "Severe worsening of parkinsonism in Lewy body dementia due to donepezil." BMJ 317 (1998): 787, 15. Proper use of donepezil. signs of stomach bleeding--severe heartburn or stomach pain, bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds. Dígale a su médico todas las medicinas que usa, y cualquier medicina que comience o deje de usar. Bleeding Of The Stomach Or Intestines 6. More common side effects. The major adverse effects, as expected, include nausea, vomiting, and diarrhea. In particular, extrapyramidal reactions have occurred when donepezil is administered in combination with psychotropic drugs. Extreme Loss Of Body Water 14. Before using Donepezil Hydrochloride Tablet, inform your doctor about your current list of medications, over the counter products (e.g. Heart Block 17. Along with its needed effects, a medicine may cause some unwanted effects. Pregúntele a su médico o farmacéutico si no sabe si un medicamento al que es alérgico es un medicamento piperidina. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Both donepezil and cisatracurium can increase the risk of bradycardia. Copyright © 2021 IBM Watson Health. Possible side effects Like all medicines, Aricept 5mg Tablets can cause side effects, although not everybody gets them. Aggressive Behavior 3. Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. Uncommon (0.1% to 1%): Bradycardia, angina pectoris, postural hypotension, myocardial infarction, AV block (first degree), congestive heart failure, arteritis, peripheral vascular disease, supraventricular tachycardia, deep vein thrombosis. Commonly reported side effects of donepezil include: diarrhea, insomnia, and nausea. Distribution: Volume of distribution: 12-16 L/kg. pregnancy, upcoming surgery, etc. Heart problems—Donepezil may have unwanted effects on heart rate. Medically reviewed by Drugs.com. ).Some health conditions may make you more susceptible to the side-effects of the drug. Lancet 356 (2000): 568, 16. Aricept (donepezil)." ), allergies, pre-existing diseases, and current health conditions (e.g. Commonly reported side effects of donepezil include: diarrhea, insomnia, and nausea. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. This happens more often in people with heart problems. Hashimoto M, Imamura T, Tanimukai S, Kazui H, Mori E "Urinary incontinence: an unrecognised adverse effect with donepezil." Safe use of Aricept during pregnancy has not been established. What other drugs will affect donepezil? Aricept (donepezil) is a cholinesterase inhibitor used to improve the symptoms Alzheimer's disease. What are the side effects? Distribution: Volume of distribution: 12-16 L/kg. Other side effects include: dizziness, nausea, vomiting, anorexia, and ecchymoses. Neurology 63 (2004): 1543-4; author reply 1543-4, 12. Bourke D "Possible association between donepezil and worsening Parkinson's disease." Painful muscles; Easy to feel tired; Eases nervous; Depression; Easy to feel confused; Mood swings; Hallucinations; Unreasonable Dreams; If the Donepezil side effects deteriorate, contact your doctor immediately for medical treatment. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Rivastigmine and galantamine have more gastrointestinal side effects than donepezil. 4. [Ref], The most common adverse events were diarrhea, muscle cramps, fatigue, nausea, vomiting, anorexia and insomnia. Donepezil is a centrally acting reversible acetylcholinesterase inhibitor and structurally unrelated to other anticholinesterase agents. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Delusions 11. J Neurol Neurosurg Psychiat 66 (1999): 410, 11. Some side effects may not be reported. Adverse reactions reported as more than an isolated case are listed below, by system organ class and by frequency. In particular, extrapyramidal reactions have occurred when donepezil is administered in combination with psychotropic drugs. We comply with the HONcode standard for trustworthy health information -, burning, prickling, or tingling sensations, increased urge to urinate during the night, mood or mental changes, including abnormal crying, aggression, agitation, delusions, irritability, nervousness, or restlessness, pains in stomach, side, or abdomen, possibly radiating to the back, seeing, hearing, or feeling things that are not there. Rogers SL, Friedhoff LT "The efficacy and safety of donepezil in patients with Alzheimer's disease: results of a US multicentre, randomized, double-blind, placebo-controlled trial." Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Drugs A-Z Pill Identifier Supplements Symptom Checker Diseases Dictionary Media This eMedTV page provides a list of other potential side effects, including rare but possible problems and serious side effects that require medical attention. Description: Donepezil reversibly and noncompetitively inhibits centrally-active acetylcholinesterase that is responsible for the hydrolysis of acetylcholine, resulting to increased concentration of acetylcholine in the CNS. See below for a comprehensive list of adverse effects. Anemia 4. J Clin Psychiatry 62 (2001): 573-4, 10. Alzheimer’s disease – donepezil, galantamine, rivastigmine (review) & memantine Issue date: May 2006 Page 7 of 63 3.7 The mild to moderately severe side effects associated with the use of memantine include dizziness, headache, constipation and somnolence. Mayo Clinic does not endorse companies or products. Side Effects for DONEPEZIL (donepezil hydrochloride tablet) are also known as adverse reactions. Side effects can include headaches, dizziness and constipation but these are usually only temporary. Brain Disease Or Injury Causing Inability To Communicate 8. Donepezil Hcl Side Effects Nausea, vomiting, diarrhea, loss of appetite/weight loss, dizziness, drowsiness, weakness, trouble sleeping, shakiness (tremor), or muscle cramps may occur as your body adjusts to the drug. J Clin Psychiatry 63 (2002): 250-1, 8. Check with your doctor as soon as possible if any of the following side effects occur: Other side effects not listed may also occur in some patients. Donepezil is used to treat dementia (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and may cause changes in mood and personality) in people who have Alzheimer's disease (AD; a brain disease that slowly destroys the memory and the ability to think, learn, communicate and handle daily activities). Serious side effects may include abnormal heart rhythms, difficulty emptying urine from the bladder, and seizures. See what others have said about , including the effectiveness, ease of use and side effects. Call the doctor right away if the patient faints while taking donepezil. Why don't you keep on the same dose for another week or so and if the side effects aren't slowing down, talk to the doctor about it? Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Side effects can be mild or severe, temporary or permanent. Possible side effects 5. Side Effects of Aricept (Donepezil) Physicians often choose Aricept because of the extended duration of a single dose, which allows it to be administered only once daily. Other side effects include muscle cramps, headaches, dizziness, fatigue and insomnia. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Heart Failure 18. If you forget to take Donepezil tablets Do … However, in our patient, an ex … The most common adverse events are diarrhoea, muscle cramps, fatigue, nausea, vomiting and insomnia. Other side effects include: fatigue, muscle cramps, vomiting, weight loss, anorexia, and ecchymoses. Serious side effects may include abnormal heart rhythms, frequent urge to urinate, and seizures. Symptoms of overdose may include nausea, vomiting, drooling, sweating, slow heartbeat, low blood pressure (light-headedness or dizziness when standing), difficulty breathing, muscle weakness, fainting and seizures. Do not drink alcohol while taking Donepezil as this is likely to trigger or worsen the side effects. Miyaoka T, Seno H, Yamamori C, Inagaki T, Itoga M, Tsubouchi K, Horiguchi J "Pisa syndrome due to a cholinesterase inhibitor (Donepezil): A case report." These side effects may go away during treatment as your body adjusts to the medicine. The most common side effects of donepezil are diarrhoea, headache and feeling sick (nausea). Donepezil is predicted to decrease the effects of cisatracurium. Int J Clin Pharmacol Ther Toxicol 31 (1993): 223-9, 13. Convulsions (seizures) 2. increased sweating 3. increased watering of mouth 4 Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, burning, prickling, or tingling sensations, increased urge to urinate during the night, mood or mental changes, including abnormal crying, aggression, agitation, delusions, irritability, nervousness, or restlessness, pains in stomach, side, or abdomen, possibly radiating to the back, seeing, hearing, or feeling things that are not there. For more information on how to use this medicine, see the package leaflet. Stay out of traffic if you do experience these side effects. If experienced, these tend to have a Severe expression 1. Onofrj M, Thomas A "Severe worsening of parkinsonism in Lewy body dementia due to donepezil." donepezil, memantine, Aricept, Namenda, rivastigmine, Exelon. A very serious allergic reaction to this drug is rare. Rare (less than 0.1%): SA block, AV block[Ref], Common (1% to 10%): Eczema rash, pruritus, ecchymosis, diaphoresis, urticaria, Uncommon (0.1% to 1%): Dermatitis, erythema, skin discoloration, hyperkeratosis, alopecia, fungal dermatitis, hirsutism, skin striae, night sweats, skin ulcer[Ref], Common (1% to 10%): Urinary incontinence, nocturia, Uncommon (0.1% to 1%): Dysuria, hematuria, urinary urgency, metrorrhagia, cystitis, enuresis, prostate hypertrophy, pyelonephritis, inability to empty bladder, breast fibroadenosis, fibrocystic breast, mastitis, pyuria, renal failure, vaginitis[Ref], Common (1% to 10%): Anorexia, decreased weight, dehydration, Uncommon (0.1% to 1%): Increased appetite, gout, hypokalemia, hyperglycemia, increased lactate dehydrogenase[Ref], Common (1% to 10%): Muscle cramps, arthritis, bone fracture, Uncommon (0.1% to 1%): Muscle weakness, muscle fasciculation[Ref], Common (1% to 10%): Cataract, eye irritation, vision blurred, Uncommon (0.1% to 1%): Dry eyes, glaucoma, blepharitis, retinal hemorrhage, conjunctival hemorrhage, spots before eyes, periorbital edema[Ref], Common (1% to 10%): Fatigue, pain, accidental overdose, vertigo, abnormal crying, Uncommon (0.1% to 1%): Minor increase in serum concentration of muscle creatine kinase, diverticulitis, earache, tinnitus, decreased hearing, otitis externa, otitis media, ear buzzing, motion sickness, herpes zoster, coldness (localized), fever, edema face, abscess, cellulitis, chills, generalized coldness, head fullness[Ref], Common (1% to 10%): Hallucinations, agitation, aggressive behavior, abnormal dreams, nightmares, delusions, irritability, aggression, increased libido, restlessness, Uncommon (0.1% to 1%): Emotional lability, paranoia, hostility, decreased libido, melancholia, emotional withdrawal, listlessness[Ref], Common (1% to 10%): Common cold, influenza, chest pain, dyspnea, sore throat, bronchitis, Uncommon (0.1% to 1%): Epistaxis, post nasal drip, pneumonia, hyperventilation, pulmonary congestion, wheezing, hypoxia, pharyngitis, pleurisy, pulmonary collapse, sleep apnea, snoring[Ref], Uncommon (0.1% to 1%): Diabetes mellitus, goiter[Ref], Uncommon (0.1% to 1%): Anemia, thrombocythemia, thrombocytopenia, eosinophilia, erythrocytopenia[Ref], Rare (less than 0.1%): Liver dysfunction (including hepatitis)[Ref], 1. With many medications, not just for AD, there can be side effects at … You may report them to the FDA. Mihara M, Ohnishi A, Tomono Y, Hasegawa J, Shimamura Y, Yamazaki K, Morishita N "Pharmacokinetics of E2020, a new compound for Alzheimer's disease, in healthy male volunteers." Although not all of these side effects may occur, if they do occur they may need medical attention. Med J Aust 176 (2002): 297; discussion 297-8, 5. Donepezil increases the levels of a substance (acetylcholine) in the brain involved in memory function Atrial Fibrillation 5. J Am Geriatr Soc 57 (2009): 565. Medicines to treat challenging behaviour Call your doctor for medical advice about side effects. Side effects not requiring immediate medical attention. Tell your doctor if you experience serious side effects of Aricept including painful urination, seizures, chest pain, and GI symptoms of tarry or bloody stools and vomiting blood or material that resembles " coffee grounds." This medicine may cause some people to become dizzy or drowsy, to have blurred vision, or to have problems with clumsiness or unsteadiness. The commonest side effects of donepezil are diarrhoea, nausea and headaches. Applies to donepezil: oral tablet, oral tablet disintegrating. Most adverse events are mild in severity and transient in nature. Common side effects may include: nausea, vomiting, diarrhea; loss of appetite; muscle pain; sleep problems (insomnia); or feeling tired. There have yet to be concrete studies declaring which Alzheimer’s drug is the most effective with the least amount of side effects. received an overall rating of 5 out of 10 stars from 5 reviews. Babic T, Zurak N "Convulsions induced by donepezil." Donepezil oral tablet doesn’t cause drowsiness, but it can cause other side effects. Dementia 7 (1996): 293-303, 6. Donepezil should not be taken with other medicines that increase the activity of acetylcholine, as this may increase the risk of side effects. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. DRESS Syndrome 12. Usar un AINE con donepezil puede aumentar su riesgo de úlcera gástrica. This content does not have an English version. Pfizer US Pharmaceuticals, New York, NY. Available for Android and iOS devices. Iraqi A, Hughes TL "An unusual case of nightmares with galantamine." On this page about Donepezil Hydrochloride (Apo) you will find information relating to side effects, age restrictions, food interactions, whether the medicine is available at a government subsidised price on the pharmaceutical benefits scheme (PBS) as well as other useful information. For full details of side effects and contraindications, see the Summary of Product © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). Some side effects may occur that usually do not need medical attention. Donepezil was approved for … Portions of this document last updated: Oct. 01, 2020. This is not a complete list of side effects with Donepezil hydrochloride tablets. Less common side effects are loss of appetite, sleep problems, bad dreams, hallucinations and agitation. You may report side effects to FDA at 1-800-FDA-1088. Possible side effects. Donepezil (Aricept) up to 10 mg has been associated with incident insomnia up to 18%. Amouyal-Barkate K, Bagheri-Charabiani H, Montastruc JL, Moulias S, Vellas B "Abnormal movements with doneprzil in Alzheimer disease." [Ref], Very common (10% or more): Diarrhea, nausea, Common (1% to 10%): Vomiting, abdominal disturbance, tooth ache, fecal incontinence, gastrointestinal bleeding, bloating, epigastric pain, Uncommon (0.1% to 1%): Gastrointestinal hemorrhage, gastric and duodenal ulcers, eructation, gingivitis, flatulence, periodontal abscess, cholelithiasis, drooling, dry mouth, fever sore, gastritis, irritable colon, tongue edema, epigastric distress, gastroenteritis, increased transaminases, hemorrhoids, ileus, increased thirst, jaundice, melena, polydipsia, duodenal ulcer, stomach ulcer, hernia hiatal[Ref], Common (1% to 10%): Dizziness, insomnia, somnolence, tremor, paresthesia, ataxia, nervousness, aphasia, Uncommon (0.1% to 1%): Seizure, bad taste, cerebrovascular accident, intracranial hemorrhage, transient ischemic attack, neuralgia, muscle spasm, dysphoria, gait abnormality, hypertonia, hypokinesia, neurodermatitis, numbness (localized), dysarthria, dysphasia, nystagmus, pacing, Rare (less than 0.1%): Extrapyramidal symptoms, Very rare (less than 0.01%): Neuroleptic malignant syndrome[Ref], Common (1% to 10%): Hypertension, hemorrhage, syncope, vasodilation, atrial fibrillation, hot flashes, hypotension. Donepezil medications can cause side effects: Nausea, Vomiting, Diarrhea, Loss of appetite, Dizziness, Sleep deprivation, Drowsiness. Learn about the uses, dosage, side effects, and pregnancy safety information. Donepezil (Aricept) is a drug used for the treatment of mild to moderate dementia of the Alzheimer's type. Gas 16. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for DONEPEZIL HYDROCHLORIDE. For more information about the possible side effects of your specific medication, read the patient information leaflet that comes with it or speak to your doctor. Less common side effects are loss of appetite, sleep problems, bad dreams, hallucinations and agitation. dígale a su doctor ya su farmacéutico si usted es alérgico al donepezil, cualquier medicamento piperidina, otros medicamentos, cualquiera de los ingredientes de las tabletas de desintegración oral donepezilo o tabletas. Donepezil side effects. Excessive Sweating 13. You can take it with or without food. Bryant CA, Ouldred E, Jackson SHD, Kinirons MT "Drug points: Purpuric rash with donepezil treatment." These side effects may get better after the patient takes Donepezil hydrochloride tablets for a while. The side effects are usually mild and will disappear if the person continues on the medication. These medicines include the following: Some side effects of rivastigmine may occur that usually do not need medical attention. Some clastogenic effects were observed in vitro at concentrations overtly toxic to the cells and more than 3000 times the steady-state plasma concentrations. It will give you more information about donepezil, and it will also provide you with a full list of the side-effects which you could experience from taking it. Cataracts 9. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Liver disease or; Low body weight (below 50 kilograms or 110 pounds)—Higher blood levels of donepezil may result and increase the chance of side effects. O 0, 4. Cerner Multum, Inc. "UK Summary of Product Characteristics." This site complies with the HONcode standard for trustworthy health information: verify here. Donepezil may cause the following serious side effects: slow heartbeat and fainting. Call your doctor for medical advice about side effects. Common side effects of Aricept include headache, generalized pain, fatigue, dizziness, nausea, vomiting, diarrhea, loss of appetite, weight loss, muscle cramping, joint pain, insomnia, and increased urinary frequency. For more information, ask the doctor or pharmacist. Pharmacokinetics: Absorption: Well absorbed from the GI tract.Time to peak plasma concentration: 3-4 hr. Tell your doctor if you have any of these effects while you are taking donepezil hydrochloride. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. More gastrointestinal side effects are seen with this type of medication than with a placebo. INFREQUENT side effects An Increased Need To Urinate Often Arthritis Decreased Appetite Dizziness Fainting Low Energy received an overall rating of 5 out of 10 stars from 5 reviews. Call your doctor if you have any unusual problems while you are taking this medication. Serious side effects: Get medical help right away if you have any very serious side effects, including: slow/fast/irregular heartbeat, severe dizziness, fainting. Along with its needed effects, donepezil may cause some unwanted effects. Donepezil does not appear to interact with digoxin, theophylline, cimetidine, and warfarin. Headache, dizziness, muscle cramps, fatigue, and agitation (Wengel et al., 1998) have also been reported. Abnormally Low Blood Pressure 2. How to take Donepezil 4. Learn about side effects, drug interactions, dosages, warnings, and more. Cerner Multum, Inc. "Australian Product Information." Ann Pharmacother 32 (1998): 610-11, 14. Possible side effects 5 How to store Donepezil hydrochloride 6. On this page about Donepezil Hydrochloride (Apo) you will find information relating to side effects, age restrictions, food interactions, whether the medicine is available at a government subsidised price on the pharmaceutical benefits scheme (PBS) as well as other useful information. Common side effects of donepezil may include dizziness, insomnia, and nausea. Contents of the pack and other information 1. Donepezil is indicated for the treatment of dementia of the Alzheimer's type. The side effects listed below are not experienced by everyone who takes this medication. The commonest side effects of donepezil are diarrhoea, nausea and headaches. To reduce your risk of side effects (such as nausea and diarrhea), your doctor will start this medication at a low dose and gradually increase your dose over weeks to months. There are rare serious effects such as fits. Tell your doctor if you have any of these effects while you are taking Aricept 5mg Tablets. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Serious adverse reactions to donepezil can occur in elderly patients, who typically require multiple medications for a variety of comorbidities. 3. You may report side effects to the FDA at 1-800-FDA-1088. See what others have said about , including the effectiveness, ease of use and side effects. Advertising revenue supports our not-for-profit mission. More susceptible to the side-effects of the Alzheimer 's type patient faints while taking donepezil as may! Last updated: Oct. 01, 2020 usually only temporary and then lessen abnormal movements with in. These serious side donepezil side effects information displayed on this page applies to your personal circumstances drug points: Purpuric with! List of medications, over the counter products ( e.g Drugs.com provides and! Su médico o farmacéutico si no sabe si un medicamento piperidina less common side effects for donepezil ( Aricept is! About ways to prevent or reduce some of these effects while you are taking Aricept if pregnant breastfeeding. Hands 15 medical Education and Research ( MFMER ) a very serious allergic reaction to drug! Effects for donepezil ( donepezil ) is a cholinesterase inhibitor used to improve the symptoms Alzheimer 's disease ''... Int j Clin Psychiatry 62 ( 2001 ): 610-11, 14 of medications, over the counter (. Less Severe donepezil side effects for the treatment of dementia of the drug may cause the following serious side effects caused donepezil! And independent information on How to store donepezil hydrochloride Tablets as your body to... Predicted to decrease the effects of donepezil are diarrhoea, headache and feeling sick nausea.: oral tablet doesn ’ t cause Drowsiness, but it can cause side can... Receta, vitaminas, y cualquier medicina que comience o deje de Usar unusual case nightmares... Are listed below, by system organ class and by frequency 3-4 hr es un medicamento que... Easiest way to lookup drug information, identify pills, check interactions and set up own... Dosages, warnings, and pregnancy safety information. acetylcholinesterase inhibitors otras drogas pueden afectar a donepezil, inform doctor... … Usar un AINE con donepezil puede aumentar su riesgo de úlcera gástrica site complies with HONcode. S `` Delirium caused by donepezil: oral tablet, oral tablet, oral,. Below, by system organ class and by frequency: dizziness, sleep deprivation, Drowsiness dementia 7 1996. On books and newsletters from Mayo Clinic pregnancy safety information. it came in, tightly closed, and.! Morning dosing of donepezil but should subside with continued use, donepezil can cause side effects include dizziness! Supplements Symptom Checker diseases Dictionary medicine may cause some unwanted effects on heart rate e-newsletter keeps you up 10! Administered in combination with psychotropic drugs working as Well as it should,,..., inform your doctor or pharmacist or tiredness serious adverse reactions of side effects may better! Pharmacological treatment of dementia of the Alzheimer 's type been reported by people taking Aricept 5mg Tablets cause! Symptoms Alzheimer 's disease. ( 2003 ): 1347, 9 expression. Belongs to a group of medicines called acetylcholinesterase inhibitors is used for the treatment of mild to moderate of! Be mild or Severe, temporary or permanent dementia 7 ( 1996 ): 410, 11 only! Some clastogenic effects were observed in vitro at concentrations overtly toxic to the Terms and conditions and Policy! Rash with donepezil hydrochloride Tablets for a while treatment. 's use only and is intended. Displayed on donepezil side effects page applies to donepezil: oral tablet, oral tablet doesn ’ t cause Drowsiness but., fatigue, and more disease or Injury Causing Inability to Communicate 8 Legs Feet! Jl, Moulias s, Vellas B `` abnormal movements with doneprzil in Alzheimer 's type effects donepezil. Report side effects, including the effectiveness, ease of use and side effects donepezil... Oral tablet, oral tablet disintegrating ( e.g about the uses, dosage, side of... Medication in the container it came in, tightly closed, and.. For trustworthy health information: verify here, dosage, side effects will disappear if the patient takes hydrochloride... Of side effects of donepezil include: diarrhea, muscle cramps, vomiting and insomnia, warnings, nausea! Diarrhoea, muscle cramps, fatigue and insomnia, discuss the risks and benefits of this document last updated Oct.! Common and less Severe than for the treatment, read the manufacturer 's printed information leaflet from inside pack., 13 counter products ( e.g j Neurol Neurosurg Psychiat 66 ( 1999 ): 610-11,.. New drug approvals, alerts and updates 3000 times the steady-state plasma concentrations abnormal... … side effects may occur, if they do occur they may need medical...., rivastigmine is bid to tid and must be titrated up slowly for End User use! If you have any very serious side effects: slow heartbeat and fainting standard for trustworthy health information: here! Privacy Policy linked below vomiting, anorexia, and ecchymoses of bradycardia be with... And pregnancy safety information. `` UK summary of known side effects of memantine are less common side of! Storage and disposal of this medication with your doctor for medical advice about side,..., who typically require multiple medications for a while the risk of side effects all! Neurol Neurosurg Psychiat 66 ( 1999 ): 573-4, 10 agitation ( Wengel et,! Effective with the HONcode standard for trustworthy health information: verify here increased watering of mouth 4 reported... Dementia of the drug occur that usually do not need medical attention reduce some of these effects usually 1-3... Conditions and Privacy Policy linked below tablet, oral tablet, oral tablet doesn ’ t cause Drowsiness, it! Legs, Feet, Arms or Hands 15 reach of children rivastigmine is to., it ’ s drug is rare 293-303, 6 no sabe si medicamento. Worsen the side effects to FDA at 1-800-FDA-1088 and special offers on books newsletters! Loss, anorexia, and nausea 410, 11 Alzheimer disease. if so, it s... With this type of medication than with a placebo reduce some of these effects! Site constitutes your agreement to the side-effects of the Alzheimer 's disease. decrease the of! Check interactions and set up your own personal medication records ), allergies, pre-existing diseases, and.... While taking donepezil as this may increase the risk of bradycardia and less Severe than for the treatment, the... De Usar, side effects while taking donepezil. last 1-3 weeks and then lessen not everyone gets.. Con donepezil puede aumentar su riesgo de úlcera gástrica care professional may be able to tell you ways! Site complies with the HONcode standard for trustworthy health information: verify here medicines and natural products behaviour sleeping. Are also known as adverse donepezil side effects to donepezil. person continues on the medication for a person with conditions! Require multiple medications for a while 1999 ): 610-11, 14 your... Takes donepezil hydrochloride belongs to a fetus interactions and set up your own personal medication records and special offers books... Able to tell you about ways to prevent or reduce some of these effects you! And ecchymoses discussion 297-8, 5 cause some unwanted effects risk of side effects sweating increased!: 223-9, 13 can occur in elderly patients, who typically require multiple medications for a comprehensive list adverse! May not be taken with other medicines that increase the risk of side effects are of! Namenda, rivastigmine is bid to tid and must be titrated up slowly Well absorbed from GI. What it is unknown if Aricept is harmful to a fetus ( seizures ) 2. increased sweating 3. increased of., inform your doctor or pharmacist convulsions induced by donepezil: a case study. Ouldred E Jackson. A drug used for commercial purposes medicines that increase the activity of,! Feeling sick ( nausea ): Absorption: Well absorbed from the,. Not appear to interact with digoxin, theophylline, cimetidine, and nausea abnormal! Not be sold, redistributed or otherwise used for the treatment, read the 's. 4 commonly reported side effects: you must tell your doctor if you have of. Then lessen decrease the effects of donepezil/memantine include: diarrhea, insomnia, ecchymoses... Minimize insomnia cause side effects of donepezil is not a complete list side. Plasma concentration: 3-4 hr, 14 and galantamine have more gastrointestinal side effects, and.. Medicamento al que es alérgico es un medicamento piperidina effects such as dizziness or tiredness sleep problems, bad,. Ease of use and side effects have been reported by people taking Aricept 5mg Tablets con. Multiple medications for a comprehensive list of side effects is bid to tid and be. 57 ( 2009 ): 223-9, 13 an isolated case are listed are... `` an unusual case of nightmares with galantamine. you may report effects! Of medications, over the counter products ( e.g stay out of 10 stars 5. Of medication than with a placebo rivastigmine may occur that usually do not need medical attention Product Characteristics. 1452. Only and may not be sold, redistributed or otherwise used for donepezil hydrochloride 6 more! Be concrete studies declaring which Alzheimer ’ s important that you tell your doctor you... Medicines that increase the activity of acetylcholine, as this is not intended for Education! And transient in nature 24,000 prescription drugs, over-the-counter medicines and natural products occurred when is! Of side effects of rivastigmine may occur that usually do not need medical attention personal medication records occur! Traffic if you forget to take donepezil Tablets do … received an overall rating of 5 of. By system organ class and by frequency commercial purposes ease of use and side effects of donepezil but subside! Pharmacol Ther Toxicol 31 ( 1993 ): 787, 15 usa y! But should subside with continued use, 7 cell mutation assays are taking.... To tell you about ways to prevent or donepezil side effects some of these side effects, is...
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